Haff disease • LITFL • Medical Eponym Library | 水產百科網

由EAhern-Flynn著作—Haffdiseaseisararesyndromecharacterizedbyunexplainedmyalgiaandrhabdomyolysis,oftenaccompaniedbymyoglobinuria,usually ...

Haff disease is a rare syndrome characterized by unexplained myalgia and rhabdomyolysis, often accompanied by myoglobinuria, usually occurring within 24-72 hours of consuming certain types of freshwater or saltwater fish, or crustacean.

Haff disease has been identified during seasonal outbreaks in Europe, but can also occur sporadically or in small clusters. Most cases are associated with the consumption of cooked freshwater fish, although case clusters have also been reported following with boiled crayfish in Louisiana (2001[1]) and China (2011–2013[2]). A cluster has been identified amongst consumers of cowfish (alternatively known as boxfish) (Umisuzume, Lactoria diaphana), a saltwater fish, in Japan (2008-2009)[3].

The majority of reported cases have been associated with freshwater fish, unlike other seafood-related illnesses such as ciguatera[4], scombroid[5], or paralytic shellfish poisoning[6], which are associated with saltwater fish.

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